Rheumatoid arthritis (RA) is the most common persistent inflammatory arthritis, occurring throughout the world and in all ethnic groups. The prevalence is lowest in black Africans and Chinese, and highest in Pima Indians. In Caucasians, approximately 0.8–1.0% are affected, with a female to male ratio of 3 : 1. The clinical course is prolonged, with intermittent exacerbations and remissions. Patients with RA have an increased mortality when compared with age-matched controls, primarily due to an increased risk of cardiovascular disease.
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