The most common cause of osteomalacia and rickets is vitamin D deficiency, which can result from either lack of sunlight exposure, from which the majority of vitamin D is derived; dietary deficiency or malabsorption of vitamin D in patients with gastrointestinal disease.
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Systemic lupus erythematosus (SLE) is a rare disease with a prevalence that ranges from about 0.03% in Caucasians to 0.2% in Afro-Caribbeans. Some 90% of affected patients are female and the peak age at onset is between 20 and 30 years.
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Rheumatoid arthritis (RA) is the most common persistent inflammatory arthritis, occurring throughout the world and in all ethnic groups. The prevalence is lowest in black Africans and Chinese, and highest in Pima Indians. In Caucasians, approximately 0.8–1.0% are affected, with a female to male ratio of 3 : 1. The clinical course is prolonged, with intermittent exacerbations and remissions. Patients with RA have an increased mortality when compared with age-matched controls, primarily due to an increased risk of cardiovascular disease.
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Gout is an inflammatory disease caused by deposition of monosodium urate monohydrate crystals in and around synovial joints.
Causes of hyperuricaemia and gout
Diminished renal excretion
- Increased renal tubular reabsorption
- Renal failure
- Lead toxicity
- Alcohol
- Drugs
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Osteoarthritis (OA) is by far the most common form of arthritis. It is strongly associated with ageing and is a major cause of pain and disability in older people. Osteoarthritis is characterised by focal loss of articular cartilage, subchondral osteosclerosis, osteophyte formation at the joint margin, and remodelling of joint contour with enlargement of affected joints.
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