Gout is an inflammatory disease caused by deposition of monosodium urate monohydrate crystals in and around synovial joints.
Causes of hyperuricaemia and gout
Diminished renal excretion
- Increased renal tubular reabsorption
- Renal failure
- Lead toxicity
- Alcohol
- Drugs
Increased intake
- Red meat
- Seafood
Over-production of uric acid
- Myeloproliferative and lymphoproliferative disease
- Psoriasis
- High fructose intake
- Inherited disorders
Sign symptoms
- Rapid onset, reaching maximum severity in 2–6 hours, and often waking the patient in the early morning.
- severe pain, often described as the ‘worst pain ever’
- Extreme tenderness, such that the patient is unable to wear a sock or to let bedding rest on the joint
- Marked swelling with overlying red, shiny skin
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Posted in Category: Musculoskeletal Disorders
